VELscope Oral Cancer ScreeningThe VELscope is a device that offers a painless and non-invasive way to screen for abnormal tissue in the mouth. Without the need for stains or rinses, the examination takes only one or two minutes. The VELscopeĀ® System Handpiece emits a safe blue light into the oral cavity, which excites the tissue, causing it to fluoresce. The clinician is then able to immediately view the different fluorescence responses to help differentiate between normal and abnormal tissue. If abnormal tissue is observed, a biopsy is ordered to determine the exact nature of the tissue.